To understand the mechanism underlying the function and dynamics of the nervous system, it is essential to develop the techniques capable of modulating and recording a diversity of signals employed by neurons. However, current approaches are limited in terms of effectiveness, side effects, or mechanical invasiveness due to its bulky body. Consequently, there is a need for new biocompatible devices or materials allowing for minimally invasive manipulation with monitoring of neural activity. Our talk will introduce two complementary strategies to address these challenges: (1) Flexible and stretchable fiber-based probes for interfacing with the brain and spinal cord; (2) Wireless magneto-thermal/mechanical technique for deep brain stimulation. These technologies enabling the interrogation with neural circuits across their diverse signaling modalities without inducing a foreign-body reaction helps the study of information processing as well as pathologies of the nervous system.